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Polynucleotides vs Profhilo: Which Treatment Is Right for Me?

  • Writer: Emma
    Emma
  • Nov 17, 2025
  • 2 min read

Updated: Dec 8, 2025


When it comes to advanced skin treatments, the options can sometimes feel overwhelming. Two of the most talked-about injectable treatments right now are Polynucleotides and Profhilo. While both are designed to rejuvenate the skin, they work in different ways and are suited to different concerns. If you’re wondering which one is right for you, here’s everything you need to know.



What Are Polynucleotides?

Polynucleotides are naturally derived molecules that help to repair, regenerate, and deeply rejuvenate the skin. They work by:

  • Stimulating collagen and elastin production.

  • Improving tissue regeneration and wound healing.

  • Providing antioxidant benefits to fight free radical damage.


    This treatment is ideal if you’re looking to address:


  • Loss of elasticity.

  • Reducing fine lines and wrinkles.

  • Dark circles or crepey under-eye skin.

  • Overall skin health and repair.


Polynucleotides are particularly popular for delicate areas such as the under-eyes, where traditional fillers may not be suitable.



What Is Profhilo?

Profhilo is a hyaluronic acid-based injectable treatment, but it’s not a filler. Instead, it acts as a bio-remodelling treatment that hydrates the skin deeply and stimulates collagen and elastin production.


Benefits of Profhilo:

  • Intense hydration from within.

  • Firmer, tighter, and smoother skin.

  • Improved skin tone and radiance.

  • Smooths fine lines.

  • Improves overall skin quality.



Profhilo is perfect for areas such as the face, neck, and décolletage, and is often chosen by clients who want an overall glow and anti-ageing boost.



Polynucleotides vs Profhilo: The Key Differences


Feature

Polynucleotides

Profhilo

Main Action

Skin repair & regeneration

Deep hydration & bio-remodelling

Best For

Under-eyes, fine lines, skin healing

Face, neck, décolletage, overall glow

Treatment Goal

Improves elasticity, repairs tissue

Boosts hydration, firms & smooths

Longevity

6–12 months (course recommended)

6-12 months (2 sessions, 4 weeks apart)


Which Skin Booster Is Right for You?

  • Choose Polynucleotides if you’re worried about crepey under-eye skin, fine lines, or loss of elasticity.

  • Choose Profhilo if you want an all-over hydration boost, natural firmness, and a radiant complexion.


Many clients see the best results from combining both treatments as part of a personalised anti-ageing plan.




Final Thoughts

Both Polynucleotides and Profhilo are highly effective skin boosters that go beyond traditional injectables, working with your skin to restore its natural health and beauty.

At Aurora Beauty Aesthetics, I offer bespoke skin rejuvenation treatments tailored to your needs. During your consultation, I will assess your skin and help you decide whether Polynucleotides, Profhilo, or a combination of both is right for you.


✨ Ready to discover glowing, youthful skin?


📍 Book your consultation today and take the first step towards radiant, rejuvenated skin.



 
 
 

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